SEARCH

SEARCH BY CITATION

Keywords:

  • asymmetric catalysis;
  • half-sandwich complexes;
  • metalloenzymes;
  • reduction;
  • transfer hydrogenation

Abstract

Dative anchoring of a piano-stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S-peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.