Nanorods with motion enhanced through biocatalytically induced self-electrophoresis are described. To obtain such nanorods, the polymer half of polypyrrole–gold (PPy-Au) nanorods is decorated with horseradish peroxidase (HRP) and their metal half with cytochrome c (Cyt c). If such nanorods are suspended in enzymatically generated mixtures of O2⋅− and H2O2, the immobilized Cyt c is reduced by O2⋅−, and the immobilized HRP is oxidized by H2O2. As both hemeproteins are capable of direct electron transfer to/from solid substrates, the oxidized HRP is subsequently reduced with electrons received, through the nanorod, from the reduced Cyt c. The combined processes cause species from the electrical double layer of the nanorods to move from one end of the nanorod to the other, which powers the motion of the nanorods in the opposite direction. The diffusive motion of the hemeprotein-modified nanorods is characterized by a diffusion coefficient 30 % larger in the presence of O2⋅− and H2O2 than in their absence. Unmodified nanorods do not show such behavior.