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2-Alkenyl Furans from a Palladium-Catalyzed Cyclization and Coupling of Ene-Yne-Ketones

Authors

  • Craig D. Smith,

    1. WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ (UK), Fax: (+44) 0141-330-6867
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  • Dr. David J. France

    Corresponding author
    1. WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ (UK), Fax: (+44) 0141-330-6867
    • WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ (UK), Fax: (+44) 0141-330-6867

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Abstract

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Furious furans: A recent article by Wang et al. reports a novel palladium-catalyzed cross-coupling reaction to form 2-alkenyl substituted furans from ene-yne-ketones. The electrophiles used in this study were benzyl, aryl and allyl bromides to yield highly substituted furans in moderate to good yields. A palladium (2-furyl)carbene is proposed as a key reactive intermediate, which is supported by DFT calculations.

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