Inside Back Cover: Hydroxynitrile Lyases Do Not Catalyse the Promiscuous Addition of Cyanide to Imines (ChemCatChem 6/2013)

Authors

  • Dr. Guzman Torrelo,

    1. Gebouw voor Scheikunde, Biokatalysis & Organische Chemie, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft (Netherlands), Fax: (+31) 15-278-1415
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  • Dr. Jianfeng Jin,

    1. Gebouw voor Scheikunde, Biokatalysis & Organische Chemie, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft (Netherlands), Fax: (+31) 15-278-1415
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  • Prof. Ulf Hanefeld

    Corresponding author
    1. Gebouw voor Scheikunde, Biokatalysis & Organische Chemie, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft (Netherlands), Fax: (+31) 15-278-1415
    • Gebouw voor Scheikunde, Biokatalysis & Organische Chemie, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft (Netherlands), Fax: (+31) 15-278-1415
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Abstract

original image

Blank reaction! The cover picture shows how hydroxynitrile lyases do not catalyze the addition of cyanide to an imine, which is mediated rather by the water present in the reaction media. In their Communication on p. 1304 ff., G. Torrelo et al. report that this addition, which is part of the classical Strecker synthesis, occurs in a non-enzymatic way and two structurally different hydroxynitrile lyases do not catalyze this reaction. These results discard the promiscuous catalytic activity attributed to these enzymes more than 10 years ago.

Cartoon 1.

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