Don't rush, take it step-by-step! The cover picture shows an effective cellulose-to-glucose-to-fructose conversion sequence in which enzyme-immobilized, Fe3O4-loaded mesoporous silica nanoparticles (MSNs) are used as recyclable biocatalysts. In their Communication on p. 2153 ff., K. C.-W. Wu et al. describe the synthesis of Fe3O4-loaded MSNs as solid catalysts, on which cellulase and isomerase are separately immobilized, for a continuous cellulose-to-glucose followed by glucose-to-fructose conversion sequence in aqueous solution. Such a sequent biological reaction achieves a high fructose yield of up to 50 %, the same as that with free enzyme. The biocatalysts would be effective, green, recyclable, and stable in various enzymatic applications.
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