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Synthesis and Peroxidase-Like Activity of Salt-Resistant Platinum Nanoparticles by Using Bovine Serum Albumin as the Scaffold

Authors

  • Shao-Bin He,

    1. Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)
    2. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
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  • Hao-Hua Deng,

    1. Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)
    2. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
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  • Dr. Ai-Lin Liu,

    1. Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)
    2. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
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  • Guang-Wen Li,

    1. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
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  • Prof. Xin-Hua Lin,

    1. Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)
    2. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
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  • Prof. Wei Chen,

    Corresponding author
    1. Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)
    2. Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou 350004 (P.R. China)
    • Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004 (P.R. China)===

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  • Prof. Xing-Hua Xia

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
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Abstract

A green approach is proposed for the synthesis of Pt nanoparticles (PtNPs) in the bovine serum albumin (BSA) scaffold through biomineralization. The resulting BSA–PtNPs have been proved to function as peroxidase mimics that can catalyze the reaction of various peroxidase substrates in the presence of H2O2. Kinetic studies indicate that BSA–PtNPs have a much higher affinity for H2O2 than the NPs of other Pt-based peroxidase mimics. Furthermore, the BSA shell plays an important role in promoting the robust stability of PtNPs. Even in high ionic strength environment (2 M NaCl), the catalytic activity can be well preserved. These excellent properties make the BSA–PtNPs an ideal candidate for a wide range of potential applications as peroxidase mimics.

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