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Palladium-Catalyzed Silver-Mediated α-Arylation of Acetic Acid: A New Approach for the α-Arylation of Carbonyl Compounds

Authors

  • Guo-Jie Wu,

    1. Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (P.R. China)
    2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (P.R. China), Fax: (+86) 0431-85262926
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  • Jing Guan,

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (P.R. China), Fax: (+86) 0431-85262926
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  • Prof. Fu-She Han,

    Corresponding author
    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (P.R. China), Fax: (+86) 0431-85262926
    • Fu-She Han, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (P.R. China), Fax: (+86) 0431-85262926===

      Yu-Long Zhao, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (P.R. China)===

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  • Dr. Yu-Long Zhao

    Corresponding author
    1. Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (P.R. China)
    • Fu-She Han, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (P.R. China), Fax: (+86) 0431-85262926===

      Yu-Long Zhao, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (P.R. China)===

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Abstract

A new approach for the α-arylation of acetic acid through Pd-catalyzed silver-mediated direct C[BOND]H arylation of acetic acid with aryl iodides was developed. This protocol provided a straightforward method for the synthesis of a diverse set of α-phenylacetic acids.

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