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Keywords:

  • aldol reaction;
  • asymmetric catalysis;
  • heterogeneous catalysis;
  • metal–organic frameworks;
  • organocatalysis

Abstract

A straightforward synthetic route to chiral metal–organic frameworks is proposed that relies on an acid–base interaction between an acid linker and a chiral primary amino acid derived diamine organocatalyst. High ee values for the aldol condensation of linear ketones and aromatic aldehydes are reported with this heterogeneous catalyst. Three consecutive catalyst reuse experiments demonstrated that the majority of the activity was preserved, as was the enantioselectivity.