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Concurrent Cross Metathesis and Enzymatic Oxidation: Enabling Off-Equilibrium Transformations



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Criss-cross catalysis: H. Zhao, J. F. Hartwig and co-workers have combined homogeneous alkene metathesis and biocatalysis in a concurrent fashion. A ruthenium–N-heterocyclic carbene (NHC) complex provides an equilibrating mixture of cross metathesis products. The selective simultaneous epoxidation by cytochrome P450 BM3 enables product yields well above the hypothetical two-step process.