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Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept

  1. P. Sá Gomes,
  2. A. E. Rodrigues*

Article first published online: 2 DEC 2011

DOI: 10.1002/ceat.201100281

Issue

Chemical Engineering & Technology

Chemical Engineering & Technology

Special Issue: Preparative Chromatography and Downstream Processing

Volume 35, Issue 1, pages 17–34, January, 2012

Additional Information

How to Cite

Sá Gomes, P. and Rodrigues, A. E. (2012), Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept. Chem. Eng. Technol., 35: 17–34. doi: 10.1002/ceat.201100281

Author Information

  1. University of Porto, Faculty of Engineering, Department of Chemical Engineering, Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Porto, Portugal

*University of Porto, Faculty of Engineering, Department of Chemical Engineering, Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Porto, Portugal

Publication History

  1. Issue published online: 28 DEC 2011
  2. Article first published online: 2 DEC 2011
  3. Manuscript Accepted: 8 AUG 2011
  4. Manuscript Revised: 21 JUL 2011
  5. Manuscript Received: 31 MAY 2011

Funded by

  • Ministry of Science and Technology and Higher Education of Portugal. Grant Number: POCI/EQU/59296/2004
  • European Commission. Grant Number: 251816

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Keywords:

  • Chiral resolution;
  • Chiralpak® AD;
  • Continuous chromatographic processes;
  • Countercurrent moving bed chromatography;
  • Enantiomer separation;
  • Simulated moving bed;
  • True moving bed

Abstract

This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-α-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration.

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