Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept

Authors

  • P. Sá Gomes,

    1. University of Porto, Faculty of Engineering, Department of Chemical Engineering, Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Porto, Portugal
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  • A. E. Rodrigues

    Corresponding author
    1. University of Porto, Faculty of Engineering, Department of Chemical Engineering, Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Porto, Portugal
    • University of Porto, Faculty of Engineering, Department of Chemical Engineering, Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Porto, Portugal
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Abstract

This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-α-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration.

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