Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes



There are a number of challenges that need to be overcome in order to stimulate more synthesis chemists to adopt continuous-flow chemical processing techniques. By way of example, the use of cryogenic consumables to cool reactions is impractical on scale or over extended reaction times. Here, a solution to the problem is described with the development of a convenient laboratory device that offers chemists the benefits of continuous flow processing using an accurate thermal energy transfer block which provides long-term reaction stability and is free from water ingress.