Chemical Engineering & Technology

Cover image for Vol. 36 Issue 8

Special Issue: Industrial Crystallization

August, 2013

Volume 36, Issue 8

Pages 1275–1435

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. You have free access to this content
      Cover Chem. Eng. Technol. 8/2013

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201390037

  2. Editorial Board

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. Editorial Board Chem. Eng. Technol. 8/2013

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201390038

  3. Overview

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
  4. Contents

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. You have free access to this content
  5. Highlights

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
  6. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. You have free access to this content
      Industrial Crystallization: Trends and Challenges (page 1286)

      Zuoliang Sha, Qiuxiang Yin and Jianxin Chen

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201390042

  7. Research Articles

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. Excipients-Induced Salt-to-Free Base Phase Transformation (pages 1287–1291)

      H. Qu, M. C. R. Serrat, L. P. Christensen and J. Rantanen

      Version of Record online: 25 APR 2013 | DOI: 10.1002/ceat.201300054

      Thumbnail image of graphical abstract

      The mechanisms of the transformation from salt to free form drug during processing of a model drug are investigated with special emphasis on the interplay of salt solubility and pH of the excipients. The obtained results can provide a reliable guidance for selecting excipients for robust formulation design of solid dosage pharmaceuticals in salt forms.

    2. Novel Glutaric Acid Cocrystal Formation via Cogrinding and Solution Crystallization (pages 1292–1299)

      L. Bian, H. Zhao, H. Hao, Q. Yin, S. Wu, J. Gong and W. Dong

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201200720

      Thumbnail image of graphical abstract

      A novel approach to discover new pharmaceutical cocrystals in the early development stage is applied to develop cocrystals of piracetam with some aliphatic diacids. A 1:1 cocrystal of piracetam and glutaric acid is screened by a mechanochemical method and the process of cocrystal formation during solution-mediated phase transformation is discussed.

    3. Insights into the Evaporation Kinetics of Indomethacin Solutions (pages 1300–1306)

      S. Hellstén, B. Han, E. Mäkilä, H. Niemi, J. Salonen, V.-P. Lehto, T. Stelzer, M. Louhi-Kultanen and J. Ulrich

      Version of Record online: 4 JUL 2013 | DOI: 10.1002/ceat.201200718

      Thumbnail image of graphical abstract

      Controlling crystal polymorphism is a challenging task. The effect of crystallization conditions on the crystal polymorphs of indomethacin was studied by evaporation crystallization from a free solvent surface and in a mesoporous solid material. The approach was based on a mass transfer model of evaporation and experimental solvent flux measurements were used for model evaluation.

    4. Scale-up of a Fluidized Bed Crystallizer on the Basis of Solid Suspension (pages 1307–1312)

      Z. Sha, C. Xiong and Q. Chen

      Version of Record online: 9 JUL 2013 | DOI: 10.1002/ceat.201300018

      Thumbnail image of graphical abstract

      The scale-up of crystallization processes is an important research area and has been studied for many years. The scale-up of a fluidized bed crystallizer was studied based on the solid spatial concentration distribution in the crystallizer. A strategy for the scale-up of the crystallization process was suggested based on the different states of solid suspension.

    5. Population Balance Modeling of the Solution-Mediated Transformation of DL-Methionine Polymorphs (pages 1313–1319)

      L. Wantha and A. E. Flood

      Version of Record online: 4 JUL 2013 | DOI: 10.1002/ceat.201300034

      Thumbnail image of graphical abstract

      The population balance equation (PBE) model for crystallization and the solution-mediated transformation (SMT) of the metastable α-DL-methionine into the stable γ-DL-methionine in water was derived. The crystallization and dissolution kinetics of each polymorph were applied to the PBE model and compared with the results from the SMT experiment.

    6. Kinetic Study on Polyethylenimine-Assisted Reactive Crystallization of Monodisperse Strontium Sulfate Microcrystals (pages 1320–1326)

      T. Mikami and I. Hirasawa

      Version of Record online: 8 JUL 2013 | DOI: 10.1002/ceat.201200276

      Thumbnail image of graphical abstract

      The effect of polyethylenimine (PEI) addition on nucleation and growth of SrSO4 is determined and a simple kinetic model is proposed. Time-dependent behaviors of crystal size and crystal number are statistically analyzed by a nonlinear least-square program. Kinetic aspects under the condition of obtaining monodisperse crystals are discussed.

    7. Solution-Mediated Phase Transformation of a Hydrate to its Anhydrous Form of Donepezil Hydrochloride (pages 1327–1334)

      T. Liu, B. Wang, W. Dong and J. Gong

      Version of Record online: 9 JUL 2013 | DOI: 10.1002/ceat.201300131

      Thumbnail image of graphical abstract

      First studies on solution-mediated phase transformation of a hydrate (form I) to its anhydrous form (form III) of donepezil hydro-chloride are reported. Mechanisms involved in this process are investigated by in situ and offline measurement technologies. A tentative correlation between thermodynamic properties and phase transformation is presented.

    8. Investigation of Nucleation Kinetics by Nephelometric Measurements (pages 1335–1340)

      M. Parisi and A. Chianese

      Version of Record online: 5 JUL 2013 | DOI: 10.1002/ceat.201300001

      Thumbnail image of graphical abstract

      An experimental investigation of the application of a nephelometric probe to study nucleation kinetics is reported. The nephelometric signal proved to be proportional to the surface of the solids in suspension. It allowed to accurately detect the metastable zone width and the induction time and to monitor the first period of time after nucleation.

    9. Effects of Sonocrystallization on the Crystal Size Distribution of Cloxacillin Benzathine Crystals (pages 1341–1346)

      J. Li, Y. Bao and J. Wang

      Version of Record online: 5 JUL 2013 | DOI: 10.1002/ceat.201200726

      Thumbnail image of graphical abstract

      Ultrasonic technology shows great potential in the crystallization industry with respect to the effects on crystal size distribution and morphology of the products. A novel combination of conventional reactive crystallization process and insonated disturbance is introduced to prepare uniform cloxacillin benzathine crystals with fewer aggregates.

    10. Adjustment of Process Conditions in Seeded Batch Cooling Crystallization (pages 1347–1354)

      J. Prlic Kardum, M. Hrkovac and M. Leskovac

      Version of Record online: 4 JUL 2013 | DOI: 10.1002/ceat.201300221

      Thumbnail image of graphical abstract

      The effects of seed addition temperature, seed surface area, seed loading, and seed origin on the granulometric properties, crystal size distribution, and polymorphism of the model amino acid glycine prepared by batch cooling crystallization were investigated. Polymorphism was examined by differential scanning calorimetry and X-ray diffraction analysis.

    11. Solvent Effect on Crystal Structure of Tetracycline Hydrochloride (pages 1355–1358)

      X. Hu, Y. Wang, Y. Zhao, G. Wang, Y. Bao and C. Xie

      Version of Record online: 10 JUL 2013 | DOI: 10.1002/ceat.201300147

      Thumbnail image of graphical abstract

      The crystal structure of tetracycline hydrochloride was predicted by single-crystal data via Bravais-Friedel-Donnay-Harker and modified attachment energy models. Based on simulations of the pure crystal, morphological modifications induced by solvents were examined by calculation of interaction energies between solvents and each cleaved crystal surface.

  8. Communication

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. Wet Flue Gas Desulfurization Process: Phase Equilibrium of a Quaternary System at Various Temperatures (pages 1359–1364)

      Z.-Y. Ji, B.-H. Song, J.-S. Yuan, Z.-Y. Wang, J. Wang and L.-M. Li

      Version of Record online: 5 JUL 2013 | DOI: 10.1002/ceat.201200724

      Thumbnail image of graphical abstract

      The phase equilibria of the system Mg2+, Ca2+//Cl, SO42–-H2O at different temperatures are decisive for producing MgSO4·7H2O using the mother liquid origin in magnesium-based wet flue gas desulfurization. The solubility of this quaternary system is evaluated by means of isothermal solution saturation.

  9. Research Articles

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. Modification of Disposable Red-Mud Catalysts for Slurry-Phase Hydrocracking of Vacuum Residue (pages 1365–1370)

      C. Nguyen-Huy, H. Kim, H. Kweon, D. K. Kim, D.-W. Kim, S. H. Oh and E. W. Shin

      Version of Record online: 5 JUL 2013 | DOI: 10.1002/ceat.201200714

      Thumbnail image of graphical abstract

      Different dissolution-precipitation methods served for modification of a disposable iron-based catalyst, red mud. The resulting materials were evaluated as catalysts for the slurry-phase catalytic hydrocracking of vacuum residue. Red mud activated by phosphoric acid treatment exhibited the best performance due to the caused particle size reduction.

    2. Transesterification of Soybean Oil with Ethylene Glycol, Catalyzed by Modified Li-Al layered double hydroxides (pages 1371–1377)

      J. Jiang, Y. Zhang, Y. Zheng and P. Jiang

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201300106

      Thumbnail image of graphical abstract

      Modified Li-Al layered double hydroxides are effective solid catalysts for transesterification of soybean oil (SBO) and ethylene glycol. They can be separated, reused, and regenerated easily and they have the potential to simplify the production process by using continuous packed-bed reactors. The SBO fatty acid esters products were anchored with end hydroxyl groups by ethylene glycol, which provide reaction sites for further modification of long chains.

    3. Partitioning Studies of Glutaminase in Polyethylene Glycol and Salt-Based Aqueous Two-Phase Systems (pages 1378–1386)

      S. Bolar, P. D. Belur and R. Iyyaswami

      Version of Record online: 24 JUL 2013 | DOI: 10.1002/ceat.201200677

      Thumbnail image of graphical abstract

      Commercially valuable glutaminase produced from Zygosaccharomyces rouxii NRRL-Y 2547 was partitioned in polyethylene glycol (PEG)-salt aqueous two-phase systems. Effects of salt type and concentration, PEGs with different molecular weight, and tie line lengths on partitioning and purification factor were evaluated and defined for optimum results.

    4. Beckmann Rearrangement of Cyclohexanone Oxime in a Microreactor Setup with Internal Recirculation (pages 1387–1394)

      N. T. Zuidhof, M. H. J. M. de Croon, J. C. Schouten and J. T. Tinge

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/ceat.201300088

      Thumbnail image of graphical abstract

      A microreactor setup with internal recirculation operated in continuous mode was used to demonstrate Beckmann rearrangement of cyclohexanone oxime dissolved in cyclooctane with oleum to ϵ-caprolactam. At 100 °C, the conversion of cyclohexanone oxime was complete; selectivity towards ϵ-caprolactam was 99 %. However, cyclooctane as solvent reduced the purity of the produced ϵ-caprolactam.

    5. Power Consumption of Liquid and Liquid/Solid Systems in a Rotating-Drum Bioreactor (pages 1395–1401)

      Z. Wang, S. Wen, Q. Zhang, G. Liu, X. Wu and W. Cong

      Version of Record online: 5 JUL 2013 | DOI: 10.1002/ceat.201200523

      Thumbnail image of graphical abstract

      The effects of lifter arrangement and operation conditions on power consumption in a rotating-drum bioreactor (RDB) were investigated. Empirical correlations of the power number related to reactor configuration and operation parameters are proposed for liquid and liquid/solid systems to estimate the power consumption for RDB design and scale-up.

    6. Improving Physical Absorption of Carbon Dioxide by Ionic Liquid Dispersion (pages 1402–1410)

      H. Liu, H. Tian, H. Yao, D. Yu, W. Zhao and X. Bai

      Version of Record online: 4 JUL 2013 | DOI: 10.1002/ceat.201300077

      Thumbnail image of graphical abstract

      The ionic liquid 1-butylimidazole hexafluoride phosphate [bmim]PF4 is dispersed into water to create an ionic liquid-in-water emulsion which is applied to absorb CO2. The presence of dispersed ionic liquid droplets significantly enhances the CO2 mass transfer rate at a gas-liquid interface due to both the shuttle effect and hydrodynamic effect.

    7. Chemical and Enzymatic Polymerization of Polyaniline/Ag Nanocomposites (pages 1411–1416)

      M. R. Nabid, S. Asadi, R. Sedghi and A. Bayandori Moghaddam

      Version of Record online: 9 JUL 2013 | DOI: 10.1002/ceat.201200641

      Thumbnail image of graphical abstract

      Enzymatic polymerization is a powerful tool to synthesize electronically and optically active polymers. Polyaniline/Ag nanocomposites were obtained using chemical and enzymatic polymerization of aniline based on 2-aminothiophenol-capped Ag nanoparticles. The enzymatic method resulted in smaller nanocomposites with higher thermal stability compared to the chemical method.

    8. Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers (pages 1417–1429)

      S. Swernath, M. Kaspereit and A. Kienle

      Version of Record online: 10 JUL 2013 | DOI: 10.1002/ceat.201200279

      Thumbnail image of graphical abstract

      Dynamics and control of an enantioseparation by coupled continuous chromatography and subsequent crystallization with recycle of the mother liquor were studied. The combination of both processes can improve significantly the separation efficiency. Some simple control strategies are proposed to compensate unforeseen disturbances and stabilize the process.

  10. Communication

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. Sequestration of Carbon Dioxide with Simultaneous Formation of Fine Calcium Carbonate Particles in Liposomes (pages 1430–1434)

      M. Yoshimoto and T. Koyama

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/ceat.201200412

      Thumbnail image of graphical abstract

      CaCO3 particles can be synthesized by mixing CaCl2-containing liposome suspension and CO2-saturated water as demonstrated by scanning transmission electron microscopy and energy-dispersive X-ray spectroscopy. The liposomal reaction system can be applied to the formation of fine CaCO3 particles through sequestration of CO2 under optimized conditions.

  11. Overview

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Highlights
    7. Editorial
    8. Research Articles
    9. Communication
    10. Research Articles
    11. Communication
    12. Overview
    1. You have free access to this content

SEARCH

SEARCH BY CITATION