Sterilization of Medical Products from Collagen by Means of Supercritical CO2 (pages 1891–1895)
Volker Herdegen, Alexander Felix, Roland Haseneder, Jens-Uwe Repke, Kathrin Leppchen-Fröhlich, Ina Prade and Michael Meyer
Article first published online: 6 JUN 2014 | DOI: 10.1002/ceat.201300679
Due to its favorable properties, collagen is increasingly used in medical devices. Nowadays, the necessary sterilization of this sensitive material may be conducted only by ethylenoxide and γ irradiation. To overcome the drawbacks connected to those methods, a new sterilization procedure using supercritical CO2 and the addition of small amounts of sterilization aid is successfully tested.