Challenges in Nanogrinding of Active Pharmaceutical Ingredients (pages 840–846)
André Bitterlich, Christina Laabs, Eike Busmann, Arnaud Grandeury, Michael Juhnke, Heike Bunjes and Arno Kwade
Article first published online: 3 APR 2014 | DOI: 10.1002/ceat.201300697
The influence of process parameters on product quality for the milling of the active pharmaceutical ingredients fenofibrate and cinnarizine was investigated. Besides the well-known challenge regarding stabilization of the newly formed (nano)particles, a further challenge occurred: the ripening of the cinnarizine crystals during or shortly after the milling process.