Chemical Engineering & Technology

Cover image for Vol. 38 Issue 6

Special Issue: Industrial Crystallization

June, 2015

Volume 38, Issue 6

Pages 957–1095

Issue edited by: Gerard Coquerel, Nicolas Couvrat, Yohann Cartigny

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. You have free access to this content
      Cover Chem. Eng. Technol. 6/2015 (page 957)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590027

  2. Editorial Board

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Editorial Board Chem. Eng. Technol. 6/2015 (page 958)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590028

  3. Overview

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Overview Contents: Chem. Eng. Technol. 6/2015 (page 959)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590029

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. You have free access to this content
      Contents: Chem. Eng. Technol. 6/2015 (pages 960–966)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590030

  5. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. You have free access to this content
      Industrial Crystallization (page 967)

      Gerard Coquerel, Nicolas Couvrat and Yohann Cartigny

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590031

  6. Highlights

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Highlights: Chem. Eng. Technol. 6/2015 (pages 968–969)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590032

  7. Review

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Relevance of the Second Harmonic Generation to Characterize Crystalline Samples (pages 971–983)

      Florent Simon, Simon Clevers, Valérie Dupray and Gérard Coquerel

      Article first published online: 8 MAY 2015 | DOI: 10.1002/ceat.201400756

      Thumbnail image of graphical abstract

      The application of second harmonic generation-based techniques to characterize crystalline samples is presented. Several examples are detailed for chemical purity, structural purity and polymorphism studies, with particular relevance to the pharmaceutical industry where crystalline active pharmaceutical ingredients are often made of a single enantiomer and are therefore non-centrosymmetric.

  8. Research Articles

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Generation of Crystalline Microcontainers of Salicylic Acid (pages 984–990)

      Julia Seidel and Joachim Ulrich

      Article first published online: 8 APR 2015 | DOI: 10.1002/ceat.201400716

      Thumbnail image of graphical abstract

      The formation of liquid inclusions in crystals could offer the option to generate microcontainer systems by means of controlled crystallization. Crystals containing large inclusions are necessary in order to fill them with another substance. Optimization of the inclusion sizes of salicylic acid crystals by means of antisolvent crystallization is investigated.

    2. Production of High-Tensile-Strength Paracetamol Tablets Using the Freeze-Casting Process (pages 991–998)

      Phuong Thi Nhat Nguyen and Joachim Ulrich

      Article first published online: 6 MAY 2015 | DOI: 10.1002/ceat.201400700

      Thumbnail image of graphical abstract

      Low tensile strength limits the applicability of freeze-casted tablets in industrial production. Modified starch may serve as a binder for solid particles of the active pharmaceutical ingredient enhancing the mechanical strength of produced tablets. Freeze-casted paracetamol tablets are able to compete with commercial compressed tablets in terms of disintegration time and tensile strength.

    3. Crystallization of Terutroban Sodium Salt Hydrate from the Deliquescent State (pages 999–1005)

      Nicolas Couvrat, Yohann Cartigny, Julie Linol, Lucile Vaysse-Ludot, Pascal Langlois and Gérard Coquerel

      Article first published online: 8 APR 2015 | DOI: 10.1002/ceat.201400692

      Thumbnail image of graphical abstract

      Besides studies on the crystallization processes of active pharmaceutical ingredients, stability studies at varying temperature and relative humidity are required. With Terutroban sodium salt as an example, the appearance of a hydrate (initially undesired) during storage is rationalized and its improvements in terms of stability are demonstrated.

    4. Isomer Treatment by Additive Application in the Liquid Stage as Known from Industrial Crystallization (pages 1006–1010)

      Franziska Kreißig, Christian Schäfer, Elodie Verdurand and Joachim Ulrich

      Article first published online: 24 APR 2015 | DOI: 10.1002/ceat.201400673

      Thumbnail image of graphical abstract

      The principle of additive usage in crystallization was exploited to enhance the stability of dissolved all-trans astaxanthin (AXT), which is in high demand for feed supplementation. A variety of substances/factors triggers the isomerization and/or degradation of AXT. Application of an additive in solution provides the AXT-employing industries with a tool to improve their production economics.

    5. Growth Rate Dispersion at the Single-Crystal Level (pages 1011–1016)

      Emilie Bobo, Samuel Petit and Gérard Coquerel

      Article first published online: 27 APR 2015 | DOI: 10.1002/ceat.201400766

      Thumbnail image of graphical abstract

      Crystal growth rate dispersion of ammonium perchlorate crystallized by evaporation of an aqueous solution at room temperature is evidenced by considering some Friedel pairs of faces. The relationship between the formation of inclusions and a high growth rate of crystal faces is highlighted. Considering the locations of the inclusions, the results demonstrate a high heterogeneity of crystal growth rates, from which the history of crystal growth can be retraced.

    6. Protein Composite Materials by Crystallization: Product and Process Design (pages 1017–1021)

      Patrick Frohberg and Joachim Ulrich

      Article first published online: 29 APR 2015 | DOI: 10.1002/ceat.201400720

      Thumbnail image of graphical abstract

      Product and process design approaches to control and optimize the properties of novel protein composite materials produced by reactive extrusion are presented. It was found that the control of crystalline structures within the protein material in conjunction with enzymatic cross-linking leads to advanced and application-oriented properties.

    7. Growth and Dissolution Kinetics of A and B Polymorphs of L-Histidine (pages 1022–1028)

      Lek Wantha and Adrian E. Flood

      Article first published online: 29 APR 2015 | DOI: 10.1002/ceat.201400732

      Thumbnail image of graphical abstract

      The essential amino acid L-histidine has shown to exhibit polymorphism and it exists in the solid phase as a stable polymorph A and a metastable polymorph B. The kinetics of growth and dissolution of the polymorphs which contribute to the rate of transformation between the polymorphs are investigated. The results indicate that the transformation is a growth-controlled process.

    8. Dynamic Search Algorithm of Solubility in a Salt-Water System Based on the Solubility Product (pages 1029–1034)

      Jianxin Chen, Zhifei Chen, Shuchun Pang, Qing Wu and Yunlong Zhong

      Article first published online: 29 APR 2015 | DOI: 10.1002/ceat.201400699

      Thumbnail image of graphical abstract

      A dynamic search algorithm is introduced to predict the solubility based on equilibrium equations and solubility product in salt-water systems. A comparison between the calculated results of the algorithm and the experimental solubility data proves the high accuracy and efficiency of this algorithm. It exhibits great potential for low-salt system dissolution equilibrium calculations.

    9. Correlation between Thermal Properties and Chemical Composition of Palm Oil Top Olein Fractions (pages 1035–1041)

      Xin Huang, Jingkang Wang, Jinbo Ouyang, Hongxun Hao, Yongli Wang, Yuan Gao, Qiuxiang Yin and Ying Bao

      Article first published online: 29 APR 2015 | DOI: 10.1002/ceat.201400597

      Thumbnail image of graphical abstract

      In the palm oil industry, the iodine value is normally determined by a titration method that uses toxic solvents. An innovative method is proposed to quickly determine the iodine value of oil samples. This approach can provide statistically similar results to those given by traditional official procedures, with the advantages of being extremely rapid and environmentally friendly.

    10. Solubility Characteristics and Crystallization Behavior of Oxalic Acid in the Presence of Sulfuric Acid (pages 1042–1046)

      Naoko Imura and Izumi Hirasawa

      Article first published online: 6 MAY 2015 | DOI: 10.1002/ceat.201400710

      Thumbnail image of graphical abstract

      For effective recovery of oxalic acid from acidic wastewater by crystallization, oxalic acid solubility was investigated and found to be influenced by sulfuric acid concentration. Based on the solubility data, cooling crystallization of oxalic acid in sulfuric acid aqueous solution was conducted. Columnar-type crystals of oxalic acid precipitated in sub-mm size.

    11. Non-Equimolar Discrete Phases Formed in the System of Malic Acid Enantiomers (pages 1047–1052)

      Anton I. Isakov, Elena N. Kotelnikova and Heike Lorenz

      Article first published online: 6 MAY 2015 | DOI: 10.1002/ceat.201400753

      Thumbnail image of graphical abstract

      Non-equimolar discrete compounds formed by malic acid S- and R-enantiomers in ratios 3:1 and 1:3 are investigated by means of X-ray powder diffraction. The corresponding S3R and SR3 compounds are found to be stable or metastable phases in dependence on synthesis conditions. The phases are characterized and discussed with regard to their identity and crystallochemical nature.

    12. Polymorphism, Size and Shape Control of Calcium Carbonate Crystals in the Presence of a Polyelectrolyte (pages 1053–1058)

      Yuko Sonobe, Hiroto Watamura and Izumi Hirasawa

      Article first published online: 6 MAY 2015 | DOI: 10.1002/ceat.201400731

      Thumbnail image of graphical abstract

      The effects of polyelectrolyte addition during reactive crystallization on the characteristics of calcium carbonate crystals were investigated. The supersaturation state, the material feed order, and the polyelectrolyte type and concentration were found to have great influence on the polymorphism, particle size and shape, and the crystal number of calcium carbonate.

    13. Inline Monitoring of Taltirelin Crystallization in Batch Cooling Mode Using Raman Spectroscopy (pages 1059–1067)

      Dang L. T. Nguyen and Kwang-Joo Kim

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201400725

      Thumbnail image of graphical abstract

      In cooling crystallization, supersaturation can be controlled by the cooling rate. Profiles of concentration are helpful for understanding polymorphic crystallization. At a low cooling rate, the α-form of taltirelin is nucleated and then transformed to the β-form. The α-form is formed at a high cooling rate, while the β-form is generated at a very slow cooling rate.

    14. Effect of Seeding and pH Conditions on the Size and Shape of Au Nanoparticles in Reduction Crystallization (pages 1068–1072)

      Hiroko Akiba, Masumi Ichiji, Hideyuki Nagao and Izumi Hirasawa

      Article first published online: 11 MAY 2015 | DOI: 10.1002/ceat.201400671

      Thumbnail image of graphical abstract

      A simple method is suggested to control the sizes and shapes of nano/submicron-sized Au particles by reduction without additive to inhibit agglomeration. The mechanism of particle growth was analyzed by TEM-monitoring the crystallization process. The mean particle diameters of the Au particles were controlled at 6–650 nm by seeding or using pH-controlled ascorbic acid solutions.

    15. Formation of Salicylic Acid/4,4′-Dipyridyl Cocrystals Based on the Ternary Phase Diagram (pages 1073–1080)

      Kyeong-Sill Lee, Kwang-Joo Kim and Joachim Ulrich

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201400738

      Thumbnail image of graphical abstract

      Physical properties of active pharmaceutical ingredients can be tuned by pharmaceutical cocrystals without changing the chemical identity. The solubility behavior of salicylic acid/4,4′-dipyridyl (SAA/4,4′-dipy) cocrystals is investigated in an ethanol solvent to improve the fundamentals of the formation mechanisms, solution behavior, and solid-state properties of these cocrystals.

    16. Size Control of Atorvastatin Calcium Particles Based on Spherical Agglomeration (pages 1081–1087)

      Songgu Wu, Kangli Li, Tianwei Zhang and Junbo Gong

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201400721

      Thumbnail image of graphical abstract

      Spherical agglomeration is an effective method to improve the flowability and compressibility of Atorvastation calcium particles. A polymorph transformation occurred during the antisolvent precipitation and agglomeration process. The final size distribution of the particles is controllable by adjusting the amount of bridging liquid and stirring speed.

  9. Communication

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. Saccharose Inversion and Metastable Zone (pages 1088–1091)

      Stefanie Selbmann, Julia Herfurth, Sandra Petersen and Joachim Ulrich

      Article first published online: 6 MAY 2015 | DOI: 10.1002/ceat.201400684

      Thumbnail image of graphical abstract

      To control the crystallization of sugar such as saccharose in foods, knowledge of the position of the process in the phase diagram, and of the metastable zone in particular, is needed. The exposure time to citric acid and the amount of acid are shown to lead to an increased saccharose inversion. The metastable zone shifts to lower temperatures, but does not change in its width during inversion.

  10. Overview

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Overview
    5. Contents
    6. Editorial
    7. Highlights
    8. Review
    9. Research Articles
    10. Communication
    11. Overview
    1. You have free access to this content
      Overview Contents: Chemie Ingenieur Technik 6/2015 (page 1095)

      Article first published online: 26 MAY 2015 | DOI: 10.1002/ceat.201590026

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