Conference Paper

Standardization initiatives in the (eco)toxicogenomics domain: a review

  1. Susanna Assunta Sansone1,*,
  2. Norman Morrison2,
  3. Philippe Rocca-Serra1,
  4. Jennifer Fostel3

Article first published online: 28 FEB 2005

DOI: 10.1002/cfg.447

Issue

Comparative and Functional Genomics

Comparative and Functional Genomics

Volume 5, Issue 8, pages 633–641, December 2004

Additional Information

How to Cite

Sansone, S. A., Morrison, N., Rocca-Serra, P. and Fostel, J. (2004), Standardization initiatives in the (eco)toxicogenomics domain: a review. Comp Funct Genom, 5: 633–641. doi: 10.1002/cfg.447

Author Information

  1. 1

    EMBL-EBI, The European Bioinformatics Institute, Cambridge CB10 1SD, UK

  2. 2

    The University of Manchester, Kilburn Building, School of Computer Science, Oxford Road, Manchester M13 9PL, UK

  3. 3

    National Institute of Environmental Health Sciences, National Center for Toxicogenomics. Research Triangle Park, NC 27709, USA

*EMBL-EBI, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.

Publication History

  1. Issue published online: 28 FEB 2005
  2. Article first published online: 28 FEB 2005
  3. Manuscript Accepted: 26 NOV 2004
  4. Manuscript Revised: 24 NOV 2004

Funded by

  • ILSI-HESI Genomics Committee
  • NERC
  • European Commission
  • NIEHS NCT

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Keywords:

  • toxicogenomics;
  • ecotoxicogenomics;
  • toxicology;
  • environment;
  • functional genomics;
  • standards;
  • database

Abstract

The purpose of this document is to provide readers with a resource of different ongoing standardization efforts within the ‘omics’ (genomic, proteomics, metabolomics) and related communities, with particular focus on toxicological and environmental applications. The review includes initiatives within the research community as well as in the regulatory arena. It addresses data management issues (format and reporting structures for the exchange of information) and database interoperability, highlighting key objectives, target audience and participants. A considerable amount of work still needs to be done and, ideally, collaboration should be optimized and duplication and incompatibility should be avoided where possible. The consequence of failing to deliver data standards is an escalation in the burden and cost of data management tasks. Copyright © 2005 John Wiley & Sons, Ltd.

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