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Keywords:

  • chemical evolution;
  • cofactors;
  • photochemistry;
  • stellar dust;
  • tetrapyrroles

A mosaic of Orion's Great Nebula (M42), a nearby starbirth region, is shown on the cover (Hubble space telescope; C. R. O'Dell (Vanderbilt University) and NASA). Dust grains covered by ice mantles are expected to be UV photoprocessed in the nebula, and in circumstellar regions during early phases of star formation. Experimental simulations revealed that precursors of biological cofactors, such as hexahydrotriazines, are constantly synthesized under these conditions. More details are given by G. M. Muñoz Caro et al. on page 4895 ff. Stéphane Le Saint at the University of Nice designed the picture.