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Full Paper
The Search for a Potentially Prebiotic Synthesis of Nucleotides via Arabinose-3-phosphate and Its Cyanamide Derivative
Article first published online: 18 JAN 2008
DOI: 10.1002/chem.200701351
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Anastasi, C., Buchet, Fabien F., Crowe, Michael A., Helliwell, M., Raftery, J. and Sutherland, John D. (2008), The Search for a Potentially Prebiotic Synthesis of Nucleotides via Arabinose-3-phosphate and Its Cyanamide Derivative. Chem. Eur. J., 14: 2375–2388. doi: 10.1002/chem.200701351
Publication History
- Issue published online: 28 FEB 2008
- Article first published online: 18 JAN 2008
- Manuscript Received: 28 AUG 2007
Funded by
- the Engineering and Physical Sciences Research Council
- Abstract
- Article
- References
- Cited By
Keywords:
- aldol reaction;
- diastereoselectivity;
- nucleotides;
- phosphorylation;
- prebiotic;
- RNA
Abstract
For the RNA world hypothesis to be accepted, the constitutional self-assembly of RNA will have to be demonstrated. Conceptually, the simplest route to RNA involves nucleotide polymerisation. Activated pyrimidine nucleotides can be derived from arabinose-3-phosphate under potentially prebiotic conditions, but the prebiotic synthesis of this sugar phosphate has not hitherto been investigated. The results of synthetic approaches involving phosphorylation, phosphate migration and 2,3-C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
C bond construction are described herein.