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Keywords:

  • bioinorganic chemistry;
  • dicopper enzymes;
  • model compounds;
  • O[BOND]O activation;
  • tyrosinase
Thumbnail image of graphical abstract

Center stage: Intermolecular phenolate binding to and hydroxylation by a bis(μ-oxo) dicopper(III) species demonstrate the ability of this core to perform tyrosinase-like reactivity. Kinetic analysis of the hydroxylation reaction (see scheme) shows remarkable similarities to aromatic hydroxylation reactions performed by side-on peroxo-type dicopper(II) species.