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Communication
Carbonyl-Substituted Titanocenes: A Novel Class of Cytostatic Compounds with High Antitumor and Antileukemic Activity
Article first published online: 2 APR 2008
DOI: 10.1002/chem.200800407
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Gansäuer, A., Winkler, I., Worgull, D., Lauterbach, T., Franke, D., Selig, A., Wagner, L. and Prokop, A. (2008), Carbonyl-Substituted Titanocenes: A Novel Class of Cytostatic Compounds with High Antitumor and Antileukemic Activity. Chemistry - A European Journal, 14: 4160–4163. doi: 10.1002/chem.200800407
Publication History
- Issue published online: 29 APR 2008
- Article first published online: 2 APR 2008
- Manuscript Received: 6 MAR 2008
Funded by
- Fonds der Chemischen Industrie. Grant Number: SFB 624
- Dr. Kleist-Stiftung
- KINDerLEBEN e.V.
Keywords:
- antitumor agents;
- apoptosis;
- metallocenes;
- titanium
Graphical Abstract
A new class of titanocene complexes such as depicted displays very high induction of apoptosis and hence selectivity against leukemia and tumor cells. First in vivo experiments (see graphic) exhibit significant inhibition of tumor growth. The correlation of biological activity with structural elements suggests the first design principles for the cytotoxicity of titanocenes.