A molecular computing platform to defend against illegal information theft and invasion is obtained by the rational control of chemical reaction sequences in a newly prepared multiswitchable fluorophore 2-(4-aminophenylethylyl)-5-methoxy-2-(2-pyridyl)thiazole. Some of the fluorescent states with distinct recognition features are only activated through input-sequence-sensitive conversions. Chemically encoded user identity information can then be transmitted from a sequential logic unit to a combinational logic circuit, and hence, result in user-specific digital functionalities. The user's password entry is authorized prior to each computing step to check not only the user's identity, but also to reconfigure the molecular platform from the standby state to the corresponding operational state. Illegal accesses to the molecular computing platform are unable to activate the operation of the trusted users due to the incorrect activation processes, thereby ensuring the information is secured against information invasions.