Concept

Dendrimers and DNA: Combinations of Two Special Topologies for Nanomaterials and Biology

  1. Anne-Marie Caminade Dr.,
  2. Cédric-Olivier Turrin Dr.,
  3. Jean-Pierre Majoral Dr.

Article first published online: 9 JUN 2008

DOI: 10.1002/chem.200800584

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 14, Issue 25, pages 7422–7432, August 28, 2008

Additional Information

How to Cite

Caminade, A.-M., Turrin, C.-O. and Majoral, J.-P. (2008), Dendrimers and DNA: Combinations of Two Special Topologies for Nanomaterials and Biology. Chem. Eur. J., 14: 7422–7432. doi: 10.1002/chem.200800584

Author Information

  1. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4 (France), Fax: (+33) 561-553-003

Publication History

  1. Issue published online: 25 AUG 2008
  2. Article first published online: 9 JUN 2008

Funded by

  • Agence Nationale de la Recherche. Grant Number: ANR-06-PCVI-0014 BIODENDRIDOT
  • CNRS

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Keywords:

  • biology;
  • dendrimers;
  • DNA;
  • nanomaterials;
  • self-assembly

Abstract

Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).

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