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Keywords:

  • asymmetric catalysis;
  • asymmetric synthesis;
  • Michael addition;
  • organocatalysis;
  • thioureas
Thumbnail image of graphical abstract

Novel chiral ureas and thioureas derived form natural α-amino acids have been prepared and tested as bifunctional organocatalysts in enantioselective nitro-Michael additions (see scheme). The reactions occurred with excellent chemical yields and up to 99 % ee.