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Concept
Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins
Article first published online: 10 JUL 2008
DOI: 10.1002/chem.200800700
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Imberty, A., Chabre, Yoann M. and Roy, R. (2008), Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins. Chem. Eur. J., 14: 7490–7499. doi: 10.1002/chem.200800700
Publication History
- Issue published online: 25 AUG 2008
- Article first published online: 10 JUL 2008
Funded by
- Consortium for Functional Glycomics. Grant Number: GM62116
- CNRS
- Vaincre la Mucoviscidose
- GDR Pseudomonas
- NSERC
- Abstract
- Article
- References
- Cited By
Keywords:
- adhesin;
- antiviral agents;
- dendrimers;
- glycomimetics;
- lectins
Abstract
Adhesion to epithelial surface is often the first step in bacterial and viral infection. In this process, the microbes use a variety of proteins for interaction with host carbohydrates presented as glycoconjugates on cell surfaces. Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage.