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Concept
Enabling Continuous-Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine-Chemical Production
Article first published online: 9 JUL 2008
DOI: 10.1002/chem.200800707
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Kockmann, N., Gottsponer, M., Zimmermann, B. and Roberge, Dominique M. (2008), Enabling Continuous-Flow Chemistry in Microstructured Devices for Pharmaceutical and Fine-Chemical Production. Chem. Eur. J., 14: 7470–7477. doi: 10.1002/chem.200800707
Publication History
- Issue published online: 25 AUG 2008
- Article first published online: 9 JUL 2008
- Abstract
- Article
- References
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Keywords:
- lithiation;
- microreactors;
- reaction dynamics;
- reactor design;
- transport phenomena
Abstract
Microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can handle small amounts of dangerous or unstable materials. The integration of reaction kinetics into fluid dynamics and transport phenomena is essential for successful application from process design in laboratory to chemical production. Strategies to implement production campaigns up to tons of pharmaceutical chemicals are discussed, based on Lonza projects.
Mikrostrukturierte Bauteile bieten überragende Transporteigenschaften für schnelle Vermischung, erhöhte Wärme- und Stoffübertragung und können geringe Mengen gefährlicher oder instabiler Stoffe handhaben. Die Integration der Reaktionskinetik in die Transportvorgänge ist wichtig für erfolgreiche Anwendungen von der Prozesssynthese im Labor bis zur Produktion. Scale-up-Strategien für die Produktion von pharmazeutischen Chemikalien werden anhand von Lonza-Projekten gezeigt.