Communication

A Crystalline B12 Dimer from β-Cyano-Neocobyrate†

  1. Shahzad Murtaza Dr.1,3,
  2. Philipp Butler Dr.1,
  3. Christoph Kratky Prof. Dr.2,
  4. Karl Gruber Prof. Dr.2,
  5. Bernhard Kräutler Prof. Dr.1

Article first published online: 4 AUG 2008

DOI: 10.1002/chem.200800809

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 14, Issue 25, pages 7521–7524, August 28, 2008

Additional Information

How to Cite

Murtaza, S., Butler, P., Kratky, C., Gruber, K. and Kräutler, B. (2008), A Crystalline B12 Dimer from β-Cyano-Neocobyrate. Chem. Eur. J., 14: 7521–7524. doi: 10.1002/chem.200800809

Author Information

  1. 1

    Institute of Organic Chemistry & Centre of Molecular Biosciences, University of Innsbruck, 6020 Innsbruck (Austria), Fax: (+43) 512-507-2892

  2. 2

    Institute of Molecular Biosciences, University of Graz, 8010 Graz, (Austria), Fax: (+43) 316-380-9850

  3. 3

    Present address: Islamabad College for Boys, ICB-G 6/3, Islamabad, H.No.1078, Gali 67, Street 41, Sector G-10/4 (Pakistan)

  1. †

    B12 refers to a vitamin B12 derivative.

Publication History

  1. Issue published online: 25 AUG 2008
  2. Article first published online: 4 AUG 2008
  3. Manuscript Received: 29 APR 2008

Funded by

  • Austrian Science Fund. Grant Number: FWF Project No. 13595
  • European Commission. Grant Number: Project Nr HPRN-CT-2002-00195

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Keywords:

  • cobalt;
  • porphyrinoids;
  • stereochemistry;
  • structure elucidation;
  • vitamins
Thumbnail image of graphical abstract

To dimerize or not to dimerize: The crystal structure of β-cyano-neocobyric acid reveals a new vitamin B12 dimerization motif (see figure) that involves α-face interactions and Co-coordinated f-propionate side chains. This motif is reminiscent of the carboxylate-bonded heme dimer in β-haematin and hemozoin, the disposal form of heme in Plasmodium malaria.

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