Both authors contributed equally to this study.
Cationic Metal–Corrole Complexes: Design, Synthesis, and Properties of Guanine-Quadruplex Stabilizers
Article first published online: 27 AUG 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Chemistry - A European Journal
Volume 14, Issue 30, pages 9431–9441, October 20, 2008
How to Cite
Fu, B., Zhang, D., Weng, X., Zhang, M., Ma, H., Ma, Y. and Zhou, X. (2008), Cationic Metal–Corrole Complexes: Design, Synthesis, and Properties of Guanine-Quadruplex Stabilizers. Chem. Eur. J., 14: 9431–9441. doi: 10.1002/chem.200800835
- Issue published online: 10 OCT 2008
- Article first published online: 27 AUG 2008
- Manuscript Received: 2 MAY 2008
- National Science of Foundation of China. Grant Number: 20672084
- National Science Fund for Distinguished Young Scholars. Grant Number: 20425206
- Cultivation Fund of the Key Scientific and Technical Innovation Project, the Ministry of Education of China. Grant Number: 706040
A series of pyridinium and quaternary ammonium copper corroles has been designed and synthesized. All new compounds have been fully characterized by NMR spectroscopy, high-resolution mass spectrometry, UV/Vis spectrscopy, and elemental analysis. Biochemical studies have indicated that all of these corrole derivatives can stabilize G-quadruplex structures, with corrole 4 being the most effective according to the results of circular dichroism (CD) melting experiments, polymerase chain reaction (PCR) stop assays, and surface plasmon resonance (SPR) experiments. Moreover, both corroles 3 and 4 tend to induce the human telomeric sequence to form hybrid G-quadruplex structures, whereas corroles 8 and 9 are more inclined to induce the human telomeric sequence to form antiparallel G-quadruplex structures.