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Selective Ruthenium-Catalyzed Hydration of Nitriles to Amides in Pure Aqueous Medium Under Neutral Conditions

Authors

  • Victorio Cadierno Dr.,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles” (Unidad Asociada al CSIC), Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 98-510-3446
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  • Javier Francos,

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles” (Unidad Asociada al CSIC), Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 98-510-3446
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  • José Gimeno Prof. Dr.

    1. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles” (Unidad Asociada al CSIC), Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 98-510-3446
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Abstract

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Simple, general, efficient, and green: Selective hydration of nitriles to amides (see scheme) can be performed in water under neutral conditions by using the novel hydrosoluble ruthenium(II) catalyst [RuCl26-C6Me6)(PTA-Bn)] (PTA-Bn=1-benzyl-3,5-diaza-1-azonia-7-phosphaadamantane chloride).

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