Communication

Diversity-Oriented Synthesis towards Conceptually New Highly Modular Aminal–Pyrrolidine Organocatalysts

  1. Adrien Quintard,
  2. Chloée Bournaud Dr.,
  3. Alexandre Alexakis Prof. Dr.

Article first published online: 30 JUL 2008

DOI: 10.1002/chem.200801212

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 14, Issue 25, pages 7504–7507, August 28, 2008

Additional Information

How to Cite

Quintard, A., Bournaud, C. and Alexakis, A. (2008), Diversity-Oriented Synthesis towards Conceptually New Highly Modular Aminal–Pyrrolidine Organocatalysts. Chem. Eur. J., 14: 7504–7507. doi: 10.1002/chem.200801212

Author Information

  1. Department of organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva (Switzerland), Fax: (+41) 22-379-32-15

Publication History

  1. Issue published online: 25 AUG 2008
  2. Article first published online: 30 JUL 2008
  3. Manuscript Received: 19 JUN 2008

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Keywords:

  • asymmetric catalysis;
  • diversity-oriented synthesis;
  • enamines;
  • Michael addition;
  • organocatalysis
Thumbnail image of graphical abstract

New family member: A conceptually new family of modular aminal–pyrrolidine organocatalysts was prepared by diversity-oriented synthesis. The catalytic properties of these organocatalysts could easily be tuned by varying the different substituents on the aminal part. Good yields and enantioselectivities up to 91 % were obtained in Michael additions to nitroolefins or vinyl sulfones (see scheme).

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