SEARCH

SEARCH BY CITATION

Keywords:

  • oxidation;
  • chiral benzoins;
  • enantioselectivity;
  • enzyme models;
  • kinetic resolution
Thumbnail image of graphical abstract

GO for it! An enantiopure galactose oxidase (GO) enzyme model has been synthesized from readily available (R)-binam and Cu(OTf)2 (see scheme; TEMPO=2,2,6,6-tetramethyl-piperidin-1-oxyl), and has been effectively used as an efficient chiral catalyst for the oxidative kinetic resolution of secondary alcohols. This is the first chiral copper-catalyzed oxidative kinetic resolution of racemic benzoins and the simplest method for the synthesis of highly important enantiomerically enriched benzoins.