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Galactose Oxidase Model: Biomimetic Enantiomer-Differentiating Oxidation of Alcohols by a Chiral Copper Complex



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GO for it! An enantiopure galactose oxidase (GO) enzyme model has been synthesized from readily available (R)-binam and Cu(OTf)2 (see scheme; TEMPO=2,2,6,6-tetramethyl-piperidin-1-oxyl), and has been effectively used as an efficient chiral catalyst for the oxidative kinetic resolution of secondary alcohols. This is the first chiral copper-catalyzed oxidative kinetic resolution of racemic benzoins and the simplest method for the synthesis of highly important enantiomerically enriched benzoins.

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