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Highly Enantioselective Conjugate Additions of Aldehydes to Vinyl Sulfones

Authors

  • Aitor Landa Dr.,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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  • Miguel Maestro Dr.,

    1. (X-ray analyses), Departamento de Química Fundamental, Facultad de Ciencias, Universidade da Coruña, Campus Zapateira s/n, 15071A Coruña (Spain)
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  • Carme Masdeu Dr.,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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  • Ángel Puente,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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  • Silvia Vera,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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  • Mikel Oiarbide Prof. Dr.,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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  • Claudio Palomo Prof. Dr.

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián (Spain), Fax: (+34) 943-015-270
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Abstract

Joined together, organocatalysts aldehydes and sulfones: A diaryl prolinol silyl ether was found to catalyse efficiently and enantioselectively the conjugate addition of aldehydes to vinyl sulfones (see scheme). The ample synthetic utility of the resulting adducts is illustrated.

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