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Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch-On Probes for Practical Application in Protein Staining and Cell Imaging

Authors

  • Peng Wu,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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  • Ella Lai-Ming Wong Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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  • Dik-Lung Ma Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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  • Glenna So-Ming Tong Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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  • Kwan-Ming Ng Dr.,

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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  • Chi-Ming Che Prof. Dr.

    1. Department of Chemistry and Open Laboratory of Chemical Biology of The Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (P.R. China), Fax: (+85) 22857-1586
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Abstract

Protein-staining platinum: The luminescent switch-on characteristic of the platinum(II) complex can be utilized for staining a series of proteins in sodium dodecyl sulfate-polyarcylamide gels, to give emissive gel images directly under UV light (see figure). The detection sensitivity for BSA protein is down to 6.0 ng, revealing potential practical applications of luminescent platinum(II) complexes in the luminescent signaling of biomolecules.

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