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Communication
Fluorinated Carbohydrates as Lectin Ligands: Versatile Sensors in 19F-Detected Saturation Transfer Difference NMR Spectroscopy
Article first published online: 22 APR 2009
DOI: 10.1002/chem.200900168
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Diercks, T., Ribeiro, J., Cañada, F. J., André, S., Jiménez-Barbero, J. and Gabius, H.-J. (2009), Fluorinated Carbohydrates as Lectin Ligands: Versatile Sensors in 19F-Detected Saturation Transfer Difference NMR Spectroscopy. Chemistry - A European Journal, 15: 5666–5668. doi: 10.1002/chem.200900168
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 22 APR 2009
- Manuscript Received: 20 JAN 2009
Funded by
- EC Marie Curie Research Training network. Grant Number: MRTN-CT2005-019561
- Ministry of Science and Innovation of Spain. Grant Number: CTQ2006-10874-C02-01
- Abstract
- Article
- References
- Cited By
Keywords:
- carbohydrates;
- drug design;
- fluorinated ligands;
- glycoconjugates;
- NMR spectroscopy
Graphical Abstract
As a novel approach for studying carbohydrate–lectin interactions spectroscopically, we combine the resolution and specificity of 19F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free 19F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.
Abstract
As a novel approach for studying carbohydrate–lectin interactions spectroscopically, we combine the resolution and specificity of 19F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free 19F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.