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Keywords:

  • aza-nickelacycles;
  • isoquinolines;
  • nickel;
  • reductive coupling;
  • zinc
Thumbnail image of graphical abstract

Aza-nickelacycles: An atom-economic nickel-catalyzed synthesis of isoquinolinium salts is reported. The salts are readily reduced to the corresponding reductive homo-coupling products and oxidized to isoquinolinones (see scheme). Isoquinolinones are important core structures for a vast number of natural products.