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Keywords:

  • alkynes;
  • glycoproteins;
  • glycosylation;
  • protein modification;
  • thiols
Thumbnail image of graphical abstract

Photoclick with proteins: Two cysteine containing peptides and the natural protein bovine serum albumin (BSA) were glycosylated (see scheme) by an alkenyl glycoside upon irradiation with visible light in the presence of a sensitizer (click thiol–ene coupling). The hyperglycosylation of BSA involved the cysteine free SH and two SH groups derived from selective photocleavage of a cystine residue.