Asymmetric Organocatalytic N-Alkylation of Indole-2-carbaldehydes with α,β-Unsaturated Aldehydes: One-Pot Synthesis of Chiral Pyrrolo[1,2-a]indole-2-carbaldehydes

Authors

  • Liang Hong Dr.,

    1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 (China), Fax: (+86)931-891-2567
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  • Wangsheng Sun,

    1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 (China), Fax: (+86)931-891-2567
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  • Chunxia Liu,

    1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 (China), Fax: (+86)931-891-2567
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  • Lei Wang,

    1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 (China), Fax: (+86)931-891-2567
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  • Rui Wang Prof. Dr.

    1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 (China), Fax: (+86)931-891-2567
    2. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon (Hong Kong)
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Errata

This article is corrected by:

  1. Errata: Asymmetric Organocatalytic N-Alkylation of Indole-2-carbaldehydes with α,β-Unsaturated Aldehydes: One-Pot Synthesis of Chiral Pyrrolo[1,2-a]indole-2-carbaldehydes Volume 16, Issue 3, 746, Article first published online: 14 January 2010

Abstract

original image

Like water from a duck's back: A highly enantioselective organocatalytic cascade aza-Michael/aldol reaction of indole-2-carbaldehydes with α,β-unsaturated aldehydes has been developed, providing an easy access to pyrrolo[1,2-a]indole-2-carbaldehydes with moderate to excellent enantioselectivities in one single reaction (see scheme).

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