Communication

Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor

  1. Fredrik Westerlund Dr.1,2,
  2. Christoffer B. Hildebrandt1,
  3. Thomas J. Sørensen1,
  4. Bo W. Laursen Dr.1

Article first published online: 9 FEB 2010

DOI: 10.1002/chem.200902965

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 16, Issue 10, pages 2992–2996, March 8, 2010

Additional Information

How to Cite

Westerlund, F., Hildebrandt, Christoffer B., Sørensen, Thomas J. and Laursen, Bo W. (2010), Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor. Chem. Eur. J., 16: 2992–2996. doi: 10.1002/chem.200902965

Author Information

  1. 1

    Nano-Science Center & Department of Chemistry, University of Copenhagen, Univeristetsparken 5, 2100 København Ø (Denmark), Fax: (+45) 3532-0214

  2. 2

    Department of Physics, University of Gothenburg, Kemivägen 9, 41296 Gothenburg (Sweden)

Publication History

  1. Issue published online: 1 MAR 2010
  2. Article first published online: 9 FEB 2010
  3. Manuscript Received: 27 OCT 2009

Funded by

  • Danish Research Council
  • FNU. Grant Number: 272-06-0102
  • Knut and Alice Wallenberg foundation

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Keywords:

  • dyes/pigments;
  • fluorescence;
  • photophysics;
  • sensors;
  • triangulenium
Thumbnail image of graphical abstract

Fluorescein ver. 2.0: A new, highly fluorescent, pH-sensitive trihydroxytrioxatriangulenium dye (H-TOTA) has been synthesised and characterised. The dye is closely related to fluorescein and may be considered to be a two-dimensional extended version. This new dye can exist in four different protonation states (see graphic) depending on the pH, and its use as a sensitive fluorescent ratiometric pH probe in a physiological buffer is demonstrated.

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