Communication

Structure-Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics

  1. Julia Revuelta Dr.1,
  2. Tatiana Vacas Dr.1,
  3. Francisco Corzana Dr.2,
  4. Carlos Gonzalez Dr.3,
  5. Agatha Bastida Dr.1,
  6. Juan Luis Asensio Dr.1

Article first published online: 16 FEB 2010

DOI: 10.1002/chem.200903003

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 16, Issue 10, pages 2986–2991, March 8, 2010

Additional Information

How to Cite

Revuelta, J., Vacas, T., Corzana, F., Gonzalez, C., Bastida, A. and Asensio, J. (2010), Structure-Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics. Chem. Eur. J., 16: 2986–2991. doi: 10.1002/chem.200903003

Author Information

  1. 1

    Departamento de Química Bio-orgánica, Instituto de Química Orgánica General (CSIC), Juan de la Cierva 3, 28006 Madrid (Spain), Fax: (+34) 91-5644853

  2. 2

    Departamento de Química, Universidad de La Rioja. UA-CSIC, Madre de Dios 51, 26006 Logroño, La Rioja (Spain)

  3. 3

    Instituto de Química-Física Rocasolano (CSIC), Serrano 11,. 28006 Madrid (Spain)

Publication History

  1. Issue published online: 1 MAR 2010
  2. Article first published online: 16 FEB 2010
  3. Manuscript Received: 30 OCT 2009

Funded by

  • Plan Nacional” (MCYT). Grant Numbers: CTQ2007-67403/BQU, CTQ2004-04994/BQU, CAM, S2009/ppq-1752

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Keywords:

  • antibiotics;
  • oligosaccharide recognition;
  • oligosaccharides;
  • RNA recognition
Thumbnail image of graphical abstract

Sugar sugar! The synthesis and evaluation of ribostamycin/kanamycin hybrids incorporating a highly crowded trisubstituted aminocyclitol unit that should provide maximum complementation with the RNA receptor are reported (see picture). Analysis shows that the existing conflicts between the different sugar rings can be significantly alleviated by a simple chemical modification, leading to an improvement in activity.

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