Communication

Poly(ethylene glycol)-Graft-Hollow Silica Vesicles for Drug Delivery

  1. Chee Leng Lay1,
  2. Hui Qi Liu2,
  3. Decheng Wu Dr.1,
  4. Ye Liu Dr.1

Article first published online: 11 FEB 2010

DOI: 10.1002/chem.200903291

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 16, Issue 10, pages 3001–3004, March 8, 2010

Additional Information

How to Cite

Lay, C., Liu, H., Wu, D. and Liu, Y. (2010), Poly(ethylene glycol)-Graft-Hollow Silica Vesicles for Drug Delivery. Chem. Eur. J., 16: 3001–3004. doi: 10.1002/chem.200903291

Author Information

  1. 1

    Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Fax: (+65) 6872-7528

  2. 2

    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798

Publication History

  1. Issue published online: 1 MAR 2010
  2. Article first published online: 11 FEB 2010
  3. Manuscript Received: 1 DEC 2009

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Keywords:

  • drug delivery;
  • hollow silica;
  • paclitaxel;
  • poly(ethylene glycol);
  • vesicles
Thumbnail image of graphical abstract

Delivery by stealth: Vesicles with porous silica shell layers and poly(ethylene glycol) (PEG) stealth layers have good stability, due to the silica layers, good dispersity in aqueous solution, without aggregation due to the PEG stealth layers, low cytotoxicity, and the capability to enter cells (see figure).

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