Small Molecule Macroarray Construction via Palladium-Mediated Carbon[BOND]Carbon Bond-Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays



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Arrays of stilbenes have been prepared in high purity by using Heck reactions on planar cellulose support, and demonstrate the compatibility of the small-molecule macroarray platform (see figure) with metal-mediated reactions for the first time. Biological screening of the stilbene library revealed several compounds with the ability to inhibit quorum sensing responses in bacteria, expanding the activity of this compound class.