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Catalytic Asymmetric Domino Michael–Henry Reaction: Enantioselective Access to Bicycles with Consecutive Quaternary Centers by Using Bifunctional Catalysts

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Domino catalysis: Two consecutive quaternary stereocenters, three functional groups, and four stereogenic centers have been created in the newly developed domino Michael–Henry reaction (see scheme) employing small amounts of a bifunctional organocatalyst.

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