SEARCH

SEARCH BY CITATION

Keywords:

  • allenes;
  • biocatalysis;
  • dynamic kinetic resolution;
  • palladium;
  • racemization
Thumbnail image of graphical abstract

At the palladium: Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active allenes in good yield and high enantiomeric purity (see scheme).