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Gold-Catalyzed Intramolecular Oxidative Cross-Coupling of Nonactivated Arenes



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An (Au)some coupling! Gold-catalyzed cascade C[BOND]O cyclizations of benzyl-substituted allenoate esters followed by intramolecular oxidative C[BOND]C cross-coupling involving aryl C[BOND]H functionalization were performed with Selectfluor as the oxidant (see scheme). This operationally simple and mild procedure benefits from complete axis-to-center chirality transfer and allows for the preparation of surprisingly uncommon tricyclic motifs.