Aryl Phosphoramides: Useful Electrophiles for Suzuki–Miyaura Coupling Catalyzed by a NiCl2/dppp System (dppp=1,3-Bis(diphenylphosphino)propane)

Authors

  • Yu-Long Zhao Dr.,

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (China), Tel: (+86) 431-8526-2936
    2. Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (China)
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  • You Li,

    1. Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024 (China)
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  • Yu Li,

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (China), Tel: (+86) 431-8526-2936
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  • Lian-Xun Gao Prof. Dr.,

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (China), Tel: (+86) 431-8526-2936
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  • Fu-She Han Prof. Dr.

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 (China), Tel: (+86) 431-8526-2936
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Abstract

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Suzuki–Miyaura coupling: We disclose a new strategy for phenol activation in the first Suzuki–Miyaura coupling of phenol derivatives activated by forming aryl bis(2-oxo-3-oxazolidinyl)phosphines as a highly efficient and broadly applicable methodology for the diverse synthesis of biaryls and heterobiaryls (see scheme). The use of readily available, stable NiCl2/dppp as the catalyst system also provides an important advance.

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