Cross-Coupling/Cyclization Reactions of Two Different Allenic Moieties


  • Benito Alcaide Prof.,

    1. Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica I, Facultad de Química, Unidad Asociada al CSIC, Universidad Complutense de Madrid, Facultad de Química, 28040-Madrid (Spain), Fax: (+34) 91-3944103
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  • Pedro Almendros Dr.,

    1. Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006 Madrid (Spain), Fax: (+34) 91-5644853
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  • Teresa Martínez del Campo Dr.

    1. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA (United Kingdom)
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The allene moiety represents an excellent building block for allene cross-coupling cyclization reactions, affording heterocyclic skeletons in a single step. This strategy is of particular interest when two different allene derivatives are involved in a series of metal-catalyzed cross-coupling heterocyclization processes. This Concept article is focused on the Pd-catalyzed union of two different allenic moieties, with cyclization of at least one of them by intramolecular cyclometalation. These new, versatile, and highly effective transformations are complex multistep processes leading to potential privileged structures that could find wide applications in related medicinal chemistry.