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Palladium-Catalyzed Sonogashira Coupling of Aryl Mesylates and Tosylates

Authors

  • Pui Ying Choy,

    1. State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932
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  • Wing Kin Chow,

    1. State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932
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  • Chau Ming So,

    1. State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932
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  • Chak Po Lau Prof. Dr.,

    1. State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932
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  • Fuk Yee Kwong Prof. Dr.

    1. State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932
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Abstract

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Up to speed: The first general and mild protocol for the Sonogashira coupling of aryl mesylates is presented (see scheme). The coupling intermediate also provides facile access to 2-substituted isoquinolines.

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