Oxidative Spirocyclization of Phenolic Sulfonamides: Scope and Applications

Authors

  • Huan Liang,

    1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1 (Canada), Fax: (+1)604-822-8710
    2. Current address: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 (USA)
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  • Prof. Dr. Marco A. Ciufolini

    Corresponding author
    1. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1 (Canada), Fax: (+1)604-822-8710
    • Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1 (Canada), Fax: (+1)604-822-8710

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Abstract

A full account of the oxidative dearomatization of para- and ortho-phenolic sulfonamides is provided together with an overview of the chemistry of the products and their elaboration to building blocks for spirocyclic alkaloids. A concise total synthesis of putative lepadiformine complements the discussion.

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