The Aromatic Carbon–Carbon ipso-Substitution Reaction

Authors

  • Prof. Sergio M. Bonesi,

    1. CIHIDECAR—CONICET, Departamento de Química Orgánica, 3er Piso, Pabellón 2, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, CP1428, Universidad de Buenos Aires (Argentina)
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  • Prof. Maurizio Fagnoni

    Corresponding author
    1. Department of Organic Chemistry, University of Pavia, Via Taramelli 10 (Italy), Fax: (+39) 0382-987316
    • Department of Organic Chemistry, University of Pavia, Via Taramelli 10 (Italy), Fax: (+39) 0382-987316
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Abstract

The aim of this review is to illustrate what we have dubbed an aromatic carbon–carbon ipso-substitution reaction in which a new Ar[BOND]C bond is formed at the expense of another Ar[BOND]C bond. The potentiality of several C-based leaving groups including alkyl, carbinol, CN, COOH, and carbonyl groups in arylation reactions will be illustrated accordingly for the preparation of biphenyl-, vinyl-, alkynyl-, and alkyl-substituted aromatics.

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