Advertisement

A Concise Total Synthesis of Amphidinolide T2

Authors

  • Dr. Huoming Li,

    1. Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953128
    Search for more papers by this author
  • Dr. Jinlong Wu,

    1. Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953128
    Search for more papers by this author
  • Dr. Jialu Luo,

    1. Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953128
    Search for more papers by this author
  • Prof. Dr. Wei-Min Dai

    1. Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953128
    2. Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (P.R. China)
    Search for more papers by this author

Abstract

original image

RCM+AD=T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0 % overall yield.

Ancillary